Not only is that possible but totally recommendable for automation purposes. You can create or update those clusters via Databricks CLI with cluster properties configured with proper JSON file. Take a look to the sample code I am using to update a cluster with a service principal account. Notice reference to service principal ID in single_user_name property:
By the way, I'm about to publish a video in my youtube channel about deployment with DABs plus other resources like this, not already included as far as I know.
