Yes, in your jobs settings there is a field called "pause_status" where you can set it to "UNPAUSED" or "PAUSED".
"schedule": {
"quartz_cron_expression": "0 15 22 * * ?",
"timezone_id": "America/Los_Angeles",
"pause_status": "UNPAUSED"
}
You can see this in our Jobs 2.0 API here with the Reset endpoint which overwrites all settings for a job.